反应详情

A solution of tert-butyl [(1R,3S)- 3-isopropyl-3-(4-[6-methyl-4-(trifluoromethyl)pyridin-2-yl]piperazin- 1 -ylcarbonyl)cyclopentyl]carbamate (200 mg, 1.65 mmol) dissolved in 4 M of HCl in 1,4-dioxane (10 mL, 40 mmol) was stirred at room temperature for 1 h. The reaction was diluted with methylene chloride, washed with saturated NaHCO3 solution, dried with sodium sulfate, filtered, and concentrated in vacuo to provide the desired product (0.15 g, 94%). LCMS calculated for C20H30F3N4O:(M+H) 399.2; found 399.2.

1. washwashed with saturated NaHCO3 solution
2. dry with materialdried with sodium sulfate
3. filtrationfiltered
4. concentrationconcentrated in vacuo