Acetic Acid → 2-(2-Methyl-3-nitrophenyl)acetic acid

HRID 1436856Notes

Reaction equation

HRID 1436856 reaction equation
[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1CC#N.[C:14]([OH:17])(=[O:16])[CH3:15].S(=O)(=O)(O)O>O>[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:15][C:14]([OH:17])=[O:16]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 1118Sulfuric AcidHCID 13530896(2-Methyl-3-nitrophenyl)acetonitrile

Product 1

HCID 135308972-(2-Methyl-3-nitrophenyl)acetic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

150 g of 2-Methyl-3-nitro phenylacetonitrile is added to 750 ml pure water and 600 ml acetic acid. 675 ml sulfuric acid is added drop wise to the reaction mixture and refluxed for 6-7 hours. After completion of reaction, 2000 ml water is added to it and stirred for 30-45 minutes, filtered and dried to give 2-Methyl-3-nitro phenylaceticacid (130-135 g).

Workup

  1. temperaturerefluxed for 6-7 hours
  2. additionis added to it
  3. filtrationfiltered
  4. customdried

Sources & evidence

ORD record
ord-1365eab2af8141cd99c4161881de6fb0
Source dataset
uspto-grants-2009_11
Patent number
US07619095B2

Reaction notes

Loading…