Phosphorus oxychloride → 2-Methyl-3-nitro phenylethyl chloride

HRID 1436858Notes

Reaction equation

HRID 1436858 reaction equation
[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:11][CH2:12]O.O=P(Cl)(Cl)[Cl:16]>C1(C)C=CC=CC=1>[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:11][CH2:12][Cl:16]

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 11998857855382-76-2

Product 1

HCID 688130092-Methyl-3-nitro phenylethyl chloride

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

2-Methyl-3-nitrophenyl ethyl alcohol (100 g) is added to toluene (500 ml). POCl3 (62 ml) is added to the reaction mixture and refluxed for 2 to 3 hrs. Toluene is distilled off completely to give 2-Methyl-3-nitro phenylethyl chloride

Workup

  1. temperaturerefluxed for 2 to 3 hrs
  2. distillationToluene is distilled off completely

Sources & evidence

ORD record
ord-ab50b5202d2f48aca903af2cde27ed11
Source dataset
uspto-grants-2009_11
Patent number
US07619095B2

Reaction notes

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