Phosphorus oxybromide → 1-(2-Bromoethyl)-2-methyl-3-nitrobenzene

HRID 1436859Notes

Reaction equation

HRID 1436859 reaction equation
[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:11][CH2:12]O.P(Br)(Br)([Br:16])=O>C1(C)C=CC=CC=1>[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:11][CH2:12][Br:16]

Participants

4

Reactant 2

HCID 24613Phosphorus oxybromideHCID 11998857855382-76-2

Product 1

HCID 688112171-(2-Bromoethyl)-2-methyl-3-nitrobenzene

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

2-Methyl-3-nitrophenyl ethyl alcohol (100 g) is added to toluene (500 ml). POBr3 (190 g) is added to the reaction mixture and refluxed for 2 to 3 hrs. Toluene is distilled off completely to give 2-Methyl-3-nitro phenylethyl bromide

Workup

  1. temperaturerefluxed for 2 to 3 hrs
  2. distillationToluene is distilled off completely

Sources & evidence

ORD record
ord-b338bc5bec7941f39008f6d23ac12730
Source dataset
uspto-grants-2009_11
Patent number
US07619095B2

Reaction notes

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