反应详情

In 40 ml of dichloromethane was dissolved 2.72 g of 2-methoxy-5-(5-trifluoromethyltetrazole-1-yl)benzaldehyde, and added thereto was 2.5 ml of 8 M methylamine in ethanol solution, 0.572 ml of acetic acid and 3.12 g of triacetoxy sodium borohydride, the mixture was stirred at room temperature for 6 hours. The reaction mixture was washed with saturated aqueous sodium hydrocarbonate solution, and the organic layers were dried and concentrate. The residue was purified by silica gel column chromatography (chloroform:methanol=49:1 to 4:1), to give 2.2 g of N-{2-methoxy-5-(5-trifluromethyltetrazole-1-yl)benzyl}-N-methylamine as shown in Table 136 below.

1. additionadded
2. washThe reaction mixture was washed with saturated aqueous sodium hydrocarbonate solution
3. customthe organic layers were dried
4. concentrationconcentrate
5. customThe residue was purified by silica gel column chromatography (chloroform:methanol=49:1 to 4:1)