2-Phenylpiperazine → HCID 135471272, compound

HRID 1437014Notes

Reaction equation

HRID 1437014 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[C:8](=O)[NH:7][C:6]=2[CH:17]=1.[C:18]1([CH:24]2[CH2:29][NH:28][CH2:27][CH2:26][NH:25]2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[C:8]([N:28]3[CH2:27][CH2:26][NH:25][CH:24]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[CH2:29]3)=[N:7][C:6]=2[CH:17]=1

Participants

3

Reactant 2

HCID 2506732-PhenylpiperazineHCID 36531168-chloro-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

Product 1

HCID 135471272HCID 135471272, compoundYield 69.4%

Procedure

8-Chloro-5,10-dihydro-dibenzo[b,e][1,4]diazepine-11-one (25 mg, 0.1 mmol) and 2-phenylpiperazine (162 mg, 1.0 mmol) were reacted according to GP4 to give 27 mg of the title compound (160FE45). MS (ESI) 389 (MH+). Purity for MH+ (UV/MS) 100/89.

Sources & evidence

ORD record
ord-420e8517e58e4bc785e267fc6c3472c7
Source dataset
uspto-grants-2009_11
Patent number
US07622461B2

Reaction notes

Loading…