Hydrochloric Acid → HCID 69056323, compound

HRID 1437061Notes

Reaction equation

HRID 1437061 reaction equation
[CH:1](=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[ClH:10].Cl.[C:12]([C:16]1[CH:21]=[CH:20][C:19]([NH:22][C:23]([NH:25][C:26]([NH2:28])=[NH:27])=[NH:24])=[CH:18][CH:17]=1)([CH3:15])([CH3:14])[CH3:13]>C(O)C>[ClH:10].[NH2:24][C:23]1[N:22]([C:19]2[CH:20]=[CH:21][C:16]([C:12]([CH3:15])([CH3:14])[CH3:13])=[CH:17][CH:18]=2)[CH:1]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])[N:27]=[C:26]([NH2:28])[N:25]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 454OctanalHCID 178441022HCID 178441022, compound

Product 1

HCID 69056323HCID 69056323, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

100 ml of ethanol, 4.3 g (33.1 mmol) of 1-octanal and 0.9 ml of concentrated hydrochloric acid were added to 6.0 g (22.2 mmol) of N1-(4-tert-butylphenyl)-biguanide hydrochloride, and the mixture was refluxed for 20 hours. The solvent was concentrated under reduced pressure, and the residue was cooled. The resulting precipitated colorless crystals were collected by filtration, and recrystallized from 80% aqueous ethanol to obtain 4.2 g of colorless crystals having a melting point of 239 to 241° C.

Workup

  1. temperaturethe mixture was refluxed for 20 hours
  2. concentrationThe solvent was concentrated under reduced pressure
  3. temperaturethe residue was cooled
  4. customThe resulting precipitated colorless crystals
  5. filtrationwere collected by filtration
  6. customrecrystallized from 80% aqueous ethanol

Sources & evidence

ORD record
ord-8be20ab69bdd419aa5ef646c3a0c32af
Source dataset
uspto-grants-2009_11
Patent number
US07622469B2

Reaction notes

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