Hydrochloric Acid → HCID 69054300, compound

HRID 1437063Notes

Reaction equation

HRID 1437063 reaction equation
[CH:1](=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].[ClH:12].Cl.[C:14]([C:18]1[CH:23]=[CH:22][C:21]([NH:24][C:25]([NH:27][C:28]([NH2:30])=[NH:29])=[NH:26])=[CH:20][CH:19]=1)([CH3:17])([CH3:16])[CH3:15]>C(O)C>[ClH:12].[NH2:26][C:25]1[N:24]([C:21]2[CH:22]=[CH:23][C:18]([C:14]([CH3:17])([CH3:16])[CH3:15])=[CH:19][CH:20]=2)[CH:1]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[N:29]=[C:28]([NH2:30])[N:27]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8175DecanalHCID 178441022HCID 178441022, compound

Product 1

HCID 69054300HCID 69054300, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

100 ml of ethanol, 5.2 g (33.3 mmol) of 1-decanal and 0.9 ml of concentrated hydrochloric acid were added to 6.0 g (22.2 mmol) of N1-(4-tert-butylphenyl)-biguanide hydrochloride, and the mixture was refluxed for 7 hours. The solvent was concentrated under reduced pressure, and the residue was cooled. The resulting precipitated crystals were filtered, and recrystallized from 80% aqueous ethanol to obtain 3.1 g of colorless crystals having a melting point of 238 to 240° C.

Workup

  1. temperaturethe mixture was refluxed for 7 hours
  2. concentrationThe solvent was concentrated under reduced pressure
  3. temperaturethe residue was cooled
  4. customThe resulting precipitated crystals
  5. filtrationwere filtered
  6. customrecrystallized from 80% aqueous ethanol

Sources & evidence

ORD record
ord-1821200c50d94ce8b06cb7ce46af6943
Source dataset
uspto-grants-2009_11
Patent number
US07622469B2

Reaction notes

Loading…