Malonic Acid → HCID 178443390, compound

HRID 1437073Notes

Reaction equation

HRID 1437073 reaction equation
C(O)(=O)C.[CH3:5][C:6]1([CH3:33])[N:11]=[C:10]([NH:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)[NH:9][C:8]([NH:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])=[N:7]1.[C:34]([OH:40])(=[O:39])[CH2:35][C:36]([OH:38])=[O:37]>C(#N)C>[C:34]([OH:40])(=[O:39])[CH2:35][C:36]([OH:38])=[O:37].[CH3:5][C:6]1([CH3:33])[N:11]=[C:10]([NH:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)[NH:9][C:8]([NH:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])=[N:7]1

Participants

4

Reactant 2

HCID 867Malonic AcidHCID 178476233HCID 178476233, compound

Product 1

HCID 178443390HCID 178443390, compoundYield 79.1%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

3.0 g (7.5 mmol) of the compound (1) of Working Example 38 was dissolved in 30 ml of 70% aqueous acetonitrile, and to the solution was added 0.85 g (8.17 mmol) of malonic acid. The mixture was dissolved by heating, and then cooled to obtain 3.0 g of colorless crystals having a melting point of 109 to 112° C.

Workup

  1. dissolutionThe mixture was dissolved
  2. temperatureby heating
  3. temperaturecooled

Sources & evidence

ORD record
ord-ecd4cbd6cb5d4028be8f696cda34dd0e
Source dataset
uspto-grants-2009_11
Patent number
US07622469B2

Reaction notes

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