Dicyandiamide → HCID 178490345, compound

HRID 1437104Notes

Reaction equation

HRID 1437104 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:12]=[CH:11][C:7]([CH2:8][CH2:9][NH2:10])=[CH:6][CH:5]=1.[C:13]([N:15]=[C:16]([NH2:18])[NH2:17])#[N:14]>C(O)CC>[ClH:1].[CH3:2][O:3][C:4]1[CH:12]=[CH:11][C:7]([CH2:8][CH2:9][NH:10][C:13]([NH:15][C:16]([NH2:18])=[NH:17])=[NH:14])=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 10005DicyandiamideHCID 200155Benzeneethanamine, 4-methoxy-, hydrochloride (1:1)

Product 1

HCID 178490345HCID 178490345, compoundYield 52%

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent

Procedure

200 ml of n-propanol was added to 30.0 g (0.16 mol) of 4-methoxyphenethylamine hydrochloride and 14.1 g (0.17 mol) of dicyanodiamide, and the mixture was refluxed for 24 hours, and cooled. The resulting precipitated crystals were filtered off, and the filtrate was concentrated and cooled. The precipitated crystals were recrystallized from n-propanol to obtain 22.6 g of colorless crystals having a melting point of 136 to 139° C.

Workup

  1. temperaturethe mixture was refluxed for 24 hours
  2. temperaturecooled
  3. customThe resulting precipitated crystals
  4. filtrationwere filtered off
  5. concentrationthe filtrate was concentrated
  6. temperaturecooled
  7. customThe precipitated crystals were recrystallized from n-propanol

Sources & evidence

ORD record
ord-1c283fc7c33b4742b10a9d1d97a47cb0
Source dataset
uspto-grants-2009_11
Patent number
US07622469B2

Reaction notes

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