HCID 68894402, compound → HCID 68895547, compound

HRID 1437153Notes

Reaction equation

HRID 1437153 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[C:10]2=[N:11][CH:12]=[CH:13][CH:14]=[C:9]2[C:8]([CH:15]2[CH2:20][CH:19]=CCN2C(OCC)=O)=[CH:7]1)=[O:5])[CH3:2]>CO>[CH2:1]([O:3][C:4]([N:6]1[C:10]2=[N:11][CH:12]=[CH:13][CH:14]=[C:9]2[C:8]([CH:15]2[CH2:20][CH2:19][N:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH2:7][CH2:8]2)=[CH:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 1

HCID 68894402HCID 68894402, compound

Product 1

HCID 68895547HCID 68895547, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.87 g of palladium, 10% (dry basis) on activated carbon (50% in water) were added over a solution of 8-48 g (24.7 mmol) of 3-(1-ethoxycarbonyl-1,2,3,6-tetrahydro-pyridinyl) pyrrolo[2,3-b]pyridine-1-carboxylic acid ethyl ester in 250 ml methanol and this mixture was hydrogenated at 2 bar for 20 hours. After filtering through Celite and removing the solvent under reduced pressure, 7.27 g (85% of yield) of the expected product were obtained.

Workup

  1. dry with material1.87 g of palladium, 10% (dry basis) on activated carbon (50% in water)
  2. filtrationAfter filtering through Celite
  3. customremoving the solvent

Sources & evidence

ORD record
ord-66cb4d9fa84540228011ab5807cd465d
Source dataset
uspto-grants-2009_11
Patent number
US07622480B2

Reaction notes

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