反应详情

Over a solution of 1.4 g (3.7 mmol) of 4-(1-furan-3-ylmethyl-1H-pyrrolo[2,3-b]pyridin-3-yl) piperidine-1-carboxylic acid tert-butyl ester in 10 ml of dichloromethane, 2.85 ml of trifluoroacetic acid were carefully added. The crude mixture was stirred at room temperature for 1 hour. The solvent was removed under reduced pressure and the crude residue was dissolved in 10 ml of ethyl acetate and washed with saturated aqueous solution of sodium carbonate and brine. After drying over sodium sulphate, filtering and removing the solvent under reduced pressure, 0.62 g (60% of yield) of the expected product were obtained.

1. customThe solvent was removed under reduced pressure
2. dissolutionthe crude residue was dissolved in 10 ml of ethyl acetate
3. washwashed with saturated aqueous solution of sodium carbonate and brine
4. dry with materialAfter drying over sodium sulphate
5. filtrationfiltering
6. customremoving the solvent