Bromomethylcyclopropane → HCID 17972995, compound

HRID 1437184Notes

Reaction equation

HRID 1437184 reaction equation
C(OC([N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[C:20]3[C:15](=[N:16][CH:17]=[CH:18][CH:19]=3)[NH:14][CH:13]=2)[CH2:8][CH2:7]1)=O)C.Br[CH2:22][CH:23]1[CH2:25][CH2:24]1>>[CH:23]1([CH2:22][N:14]2[C:15]3=[N:16][CH:17]=[CH:18][CH:19]=[C:20]3[C:12]([CH:9]3[CH2:8][CH2:7][NH:6][CH2:11][CH2:10]3)=[CH:13]2)[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 81503BromomethylcyclopropaneHCID 49759051Ethyl 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)piperidine-1-carboxylate

Product 1

HCID 17972995HCID 17972995, compound

Procedure

This compound was prepared following the procedure described in example 24, parts C and D, starting with 0.3 g (1 mmol) of 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-piperidine-1-carboxylic acid ethyl ester and 0.175 g (1.23 mmol) of bromomethylcyclopropane. After standard work-up, 0.242 g (96% of yield) of the expected product were isolated.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-5d771657c2464c5caf3196c50951f520
Source dataset
uspto-grants-2009_11
Patent number
US07622480B2

Reaction notes

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