HCID 68893738, compound → HCID 10152043, compound

HRID 1437190Notes

Reaction equation

HRID 1437190 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([CH2:6][N:7]2[C:11]3=[N:12][CH:13]=[CH:14][CH:15]=[C:10]3[C:9]([CH:16]3[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]3)=[CH:8]2)=[CH:2]1.C[O:23][C:24](=[O:36])[C:25]1[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][C:26]=1[O:32][CH2:33][CH2:34]Cl>>[Cl:31][C:28]1[CH:29]=[CH:30][C:25]([C:24]([OH:36])=[O:23])=[C:26]([O:32][CH2:33][CH2:34][N:19]2[CH2:18][CH2:17][CH:16]([C:9]3[C:10]4[C:11](=[N:12][CH:13]=[CH:14][CH:15]=4)[N:7]([CH2:6][C:3]4[CH:4]=[CH:5][O:1][CH:2]=4)[CH:8]=3)[CH2:21][CH2:20]2)[CH:27]=1

Participants

3

Reactant 2

HCID 68893738HCID 68893738, compoundHCID 68896318HCID 68896318, compound

Product 1

HCID 10152043HCID 10152043, compoundYield 11.8%

Procedure

This compound was prepared following the procedure described in example 4, parts E and F, starting with 1.5 g (5.3 mmol) of 1-furan-3-ylmethyl-3-piperidin-4-yl-1H-pyrrolo[2,3-b]pyridine and 1.7 g (6.9 mmol) of 2-(2-chloroethoxy)-4-chlorobenzoic acid methyl ester. After standard work-up and purification, 0.3 g (10% yield) of 4-chloro-2-{2-[4-(1-furan-3-ylmethyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-piperidin-1-yl]-ethoxy}-benzoic acid were obtained.

Workup

  1. customThis compound was prepared
  2. customAfter standard work-up and purification

Sources & evidence

ORD record
ord-5a7e30b189f04fa1a0126e7e9a367615
Source dataset
uspto-grants-2009_11
Patent number
US07622480B2

Reaction notes

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