2-(Bromomethyl)pyridine → HCID 17973008, compound

HRID 1437194Notes

Reaction equation

HRID 1437194 reaction equation
C(OC([N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[C:20]3[C:15](=[N:16][CH:17]=[CH:18][CH:19]=3)[NH:14][CH:13]=2)[CH2:8][CH2:7]1)=O)C.Br[CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=1>>[NH:6]1[CH2:7][CH2:8][CH:9]([C:12]2[C:20]3[C:15](=[N:16][CH:17]=[CH:18][CH:19]=3)[N:14]([CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=3)[CH:13]=2)[CH2:10][CH2:11]1

Participants

3

Reactant 2

HCID 5642092-(Bromomethyl)pyridineHCID 49759051Ethyl 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)piperidine-1-carboxylate

Product 1

HCID 17973008HCID 17973008, compound

Procedure

This compound was prepared following the procedure described in example 24, parts C and D, starting with 0.2 g (0.66 mmol) of 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-piperidine-1-carboxylic acid ethyl ester and 0.149 g (0.86 mmol) of 2-bromomethylpyridine. After standard work-up, 0.21 g (72% of yield) of the expected product were isolated.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-f9f294a73837460dbbe2b5922158daed
Source dataset
uspto-grants-2009_11
Patent number
US07622480B2

Reaction notes

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