Methyl 2-(2-chloroethoxy)benzoate → HCID 68896923, compound

HRID 1437196Notes

Reaction equation

HRID 1437196 reaction equation
[CH2:1]([O:3][CH2:4][CH2:5][N:6]1[C:10]2=[CH:11][N:12]=[CH:13][CH:14]=[C:9]2[C:8](N2CCCCC2)=[CH:7]1)[CH3:2].[CH3:21][O:22][C:23](=[O:34])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[O:30][CH2:31][CH2:32]Cl>>[CH3:21][O:22][C:23](=[O:34])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[O:30][CH2:31][CH2:32][N:12]1[CH2:13][CH2:14][CH:9]([C:8]2[C:9]3[C:10](=[CH:11][N:12]=[CH:13][CH:14]=3)[N:6]([CH2:5][CH2:4][O:3][CH2:1][CH3:2])[CH:7]=2)[CH2:10][CH2:11]1

Participants

3

Reactant 2

HCID 9837283Methyl 2-(2-chloroethoxy)benzoateHCID 68895650HCID 68895650, compound

Product 1

HCID 68896923HCID 68896923, compoundYield 52.1%

Procedure

This compound was prepared following the procedure described in example 4, part E, starting with 0.46 g (1.7 mmol) of 1-(2-ethoxyethyl)-3-piperidin yl-1H-pyrrolo[2,3-c]pyridine and 0.44 g (2.0 mmol) of 2-(2-chloroethoxy)-benzoic acid methyl ester. After standard work-up and purification, 0.2 g (21% yield) of 2-(2-{4-[1-(2-ethoxyethyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-piperidin-1-yl}-ethoxy)benzoic acid methyl ester were obtained.

Workup

  1. customThis compound was prepared
  2. customAfter standard work-up and purification

Sources & evidence

ORD record
ord-342ed4ba81694ddc8affc5486e48fb12
Source dataset
uspto-grants-2009_11
Patent number
US07622480B2

Reaction notes

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