2-Chloro-5-(chloromethyl)thiophene → HCID 68895141, compound

HRID 1437200Notes

Reaction equation

HRID 1437200 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[C:20]3[C:15](=[CH:16][N:17]=[CH:18][CH:19]=3)[NH:14][CH:13]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2].[Cl:21][C:22]1[S:23][C:24]([CH2:27]Cl)=[CH:25][CH:26]=1>>[CH2:1]([O:3][C:4]([N:6]1[CH2:7][CH2:8][CH:9]([C:12]2[C:20]3[C:15](=[CH:16][N:17]=[CH:18][CH:19]=3)[N:14]([CH2:27][C:24]3[S:23][C:22]([Cl:21])=[CH:26][CH:25]=3)[CH:13]=2)[CH2:10][CH2:11]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 5830792-Chloro-5-(chloromethyl)thiopheneHCID 68895624HCID 68895624, compound

Product 1

HCID 68895141HCID 68895141, compoundYield 60%

Procedure

This compound was prepared following the procedure described in example 24, part C, starting with 8.7 g (31.8 mmol) of 4-(1H-pyrrolo[2,3-c]pyridin-3-yl)-piperidine-1-carboxylic acid ethyl ester and 5.75 ml (47.7 mmol) of 2-chloro-5-chloromethylthiophen. After standard work-up and purification, 7.67 g (60% of yield) of 4-[1-(5-chlorothiophen-2-ylmethyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-piperidine-1-carboxylic acid ethyl ester were obtained.

Workup

  1. customThis compound was prepared
  2. customAfter standard work-up and purification

Sources & evidence

ORD record
ord-5aa66a50b80149a8bc94b271ce963fd2
Source dataset
uspto-grants-2009_11
Patent number
US07622480B2

Reaction notes

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