2-Chloro-5-(chloromethyl)thiophene → HCID 68895141, compound

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Reaction Steps

This compound was prepared following the procedure described in example 24, part C, starting with 8.7 g (31.8 mmol) of 4-(1H-pyrrolo[2,3-c]pyridin-3-yl)-piperidine-1-carboxylic acid ethyl ester and 5.75 ml (47.7 mmol) of 2-chloro-5-chloromethylthiophen. After standard work-up and purification, 7.67 g (60% of yield) of 4-[1-(5-chlorothiophen-2-ylmethyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-piperidine-1-carboxylic acid ethyl ester were obtained.

Provenance & Evidence