HCID 17972997, compound → HCID 68893985, compound

HRID 1437201Notes

Reaction equation

HRID 1437201 reaction equation
[Cl:1][C:2]1[S:6][C:5]([CH2:7][N:8]2[C:12]3=[CH:13][N:14]=[CH:15][CH:16]=[C:11]3[C:10]([CH:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)=[CH:9]2)=[CH:4][CH:3]=1.[CH2:23]([O:25][C:26](=[O:37])[C:27]1[CH:32]=[C:31]([CH2:33]Br)[CH:30]=[CH:29][C:28]=1[O:35][CH3:36])[CH3:24]>>[CH2:23]([O:25][C:26](=[O:37])[C:27]1[CH:32]=[C:31]([CH2:33][N:20]2[CH2:19][CH2:18][CH:17]([C:10]3[C:11]4[C:12](=[CH:13][N:14]=[CH:15][CH:16]=4)[N:8]([CH2:7][C:5]4[S:6][C:2]([Cl:1])=[CH:3][CH:4]=4)[CH:9]=3)[CH2:22][CH2:21]2)[CH:30]=[CH:29][C:28]=1[O:35][CH3:36])[CH3:24]

Participants

3

Reactant 2

HCID 17972997HCID 17972997, compoundHCID 688939465-Bromomethyl-2-methoxybenzoic acid ethyl ester

Product 1

HCID 68893985HCID 68893985, compoundYield 43.4%

Procedure

This compound was prepared following the procedure described in example 24, part E, starting with 0.44 g (1.32 mmol) of 1-(5-chlorothiophen-2-ylmethyl)-3-piperidin-4-yl-1H-pyrrolo[2,3-c]pyridine and 0.36 g (1.32 mmol) of 5-bromomethyl-2-methoxybenzoic acid ethyl ester. After standard work-up and purification, 0.3 g (43% yield) of 5-{4-[1-(5-chlorothiophen-2-ylmethyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-piperidin-1-ylmethyl}-2-methoxy-benzoic acid ethyl ester were obtained.

Workup

  1. customThis compound was prepared
  2. customAfter standard work-up and purification

Sources & evidence

ORD record
ord-73e908c8a6834d2987ca404603725782
Source dataset
uspto-grants-2009_11
Patent number
US07622480B2

Reaction notes

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