反应详情

Trifluoroacetic acid (15 mL) was added to 3,4-dimethylpiperazine-1-carboxylic acid tert-butyl ester (3.10 g) obtained from Referential Example 83 in methylene chloride (30 mL) at room temperature, followed by stirring for 1 hour. The residue obtained by removal through evaporation of the reaction solvent under reduced pressure was crystallized from chloroform-ether, and the crystals were recovered by filtration, to thereby give the title compound (2.756 g, 56%).

1. customThe residue obtained by removal through evaporation of the reaction solvent under reduced pressure
2. customwas crystallized from chloroform-ether
3. filtrationthe crystals were recovered by filtration