Trifluoroacetic acid → HCID 68440467, compound

HRID 1437223Notes

Reaction equation

HRID 1437223 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].C(OC([N:15]1[CH2:20][CH2:19][N:18]([CH3:21])[CH:17]([CH3:22])[CH2:16]1)=O)(C)(C)C>C(Cl)Cl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:21][N:18]1[CH2:19][CH2:20][NH:15][CH2:16][CH:17]1[CH3:22]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 20785237tert-Butyl 3,4-dimethylpiperazine-1-carboxylate

Product 1

HCID 68440467HCID 68440467, compoundYield 56%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (15 mL) was added to 3,4-dimethylpiperazine-1-carboxylic acid tert-butyl ester (3.10 g) obtained from Referential Example 83 in methylene chloride (30 mL) at room temperature, followed by stirring for 1 hour. The residue obtained by removal through evaporation of the reaction solvent under reduced pressure was crystallized from chloroform-ether, and the crystals were recovered by filtration, to thereby give the title compound (2.756 g, 56%).

Workup

  1. customThe residue obtained by removal through evaporation of the reaction solvent under reduced pressure
  2. customwas crystallized from chloroform-ether
  3. filtrationthe crystals were recovered by filtration

Sources & evidence

ORD record
ord-23b1817ac23744c5913e2bdedab1310d
Source dataset
uspto-grants-2009_11
Patent number
US07622471B2

Reaction notes

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