Hydrochloric Acid → 1-Isopropyl-piperazine hydrochloride

Participants

Reaction Steps

1M HCl in ethanol (40 mL) was added to 1-isopropylpiperazine-4-carboxylic acid tert-butyl ester (2.253 g) obtained from Referential Example 94, and the resultant mixture was stirred at room temperature for 17 hours, and then refluxed under heat for 1 hour. The solvent was evaporated under reduced pressure. Ethanol was added to the residue, and the insoluble solid was recovered by filtration, to thereby give the title compound (824 mg, 41%).

Provenance & Evidence