Hydrochloric Acid → 1-Isopropyl-piperazine hydrochloride

HRID 1437229Notes

Reaction equation

HRID 1437229 reaction equation
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][N:12]([CH:15]([CH3:17])[CH3:16])[CH2:11][CH2:10]1)=O)(C)(C)C>C(O)C>[ClH:1].[CH:15]([N:12]1[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]1)([CH3:17])[CH3:16]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 105613521-Boc-4-isopropylpiperazine

Product 1

HCID 161884471-Isopropyl-piperazine hydrochlorideYield 41%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1M HCl in ethanol (40 mL) was added to 1-isopropylpiperazine-4-carboxylic acid tert-butyl ester (2.253 g) obtained from Referential Example 94, and the resultant mixture was stirred at room temperature for 17 hours, and then refluxed under heat for 1 hour. The solvent was evaporated under reduced pressure. Ethanol was added to the residue, and the insoluble solid was recovered by filtration, to thereby give the title compound (824 mg, 41%).

Workup

  1. temperaturerefluxed
  2. temperatureunder heat for 1 hour
  3. customThe solvent was evaporated under reduced pressure
  4. additionEthanol was added to the residue
  5. filtrationthe insoluble solid was recovered by filtration

Sources & evidence

ORD record
ord-6be565d6e2354cbcab25bfb06fdc052e
Source dataset
uspto-grants-2009_11
Patent number
US07622471B2

Reaction notes

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