反应详情

1M HCl in ethanol (40 mL) was added to 1-isopropylpiperazine-4-carboxylic acid tert-butyl ester (2.253 g) obtained from Referential Example 94, and the resultant mixture was stirred at room temperature for 17 hours, and then refluxed under heat for 1 hour. The solvent was evaporated under reduced pressure. Ethanol was added to the residue, and the insoluble solid was recovered by filtration, to thereby give the title compound (824 mg, 41%).

1. temperaturerefluxed
2. temperatureunder heat for 1 hour
3. customThe solvent was evaporated under reduced pressure
4. additionEthanol was added to the residue
5. filtrationthe insoluble solid was recovered by filtration