反应详情

5% Palladium-carbon (200 mg) was added to 3-azido-1-benzhydrylazetidine (630 mg) obtained from Referential Example 104 in ethyl acetate (12 mL). The resultant mixture was subjected to catalytic reduction in a hydrogen atmosphere for 15 hours. The catalyst was filtered off. The solvent was evaporated under reduced pressure. The residue was purified through silica gel column chromatography (chloroform-methanol), to thereby give the title compound as a solid (410 mg, 65%).

1. filtrationThe catalyst was filtered off
2. customThe solvent was evaporated under reduced pressure
3. customThe residue was purified through silica gel column chromatography (chloroform-methanol)