Isopropanol → HCID 23090236, compound

HRID 1437248Notes

Reaction equation

C([O:3][C:4]([C:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:8]([C:17]2[CH:18]=[N:19][C:20](Cl)=[CH:21][CH:22]=2)[N:7]=1)=[O:5])C.[CH:24]([OH:27])([CH3:26])[CH3:25]>>[CH:24]([O:27][C:20]1[N:19]=[CH:18][C:17]([N:8]2[C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[CH:10][C:6]([C:4]([OH:3])=[O:5])=[N:7]2)=[CH:22][CH:21]=1)([CH3:26])[CH3:25]

Participants

Reactant 2

HCID 3776Isopropanol

HCID 86605435HCID 86605435, compound

Product 1

HCID 23090236HCID 23090236, compoundYield 81%

Procedure

The general procedure of Referential Example 125 was repeated through use of the 1-(6-chloro-3-pyridyl)-5-phenylpyrazole-3-carboxylic acid ethyl ester (1.05 g) prepared in Referential Example 123-3) and isopropanol, to thereby give the title compound as a powder (840 mg, 81%).

Sources & evidence

ORD record: ord-571115e711a04479842be5c2ffe1506f
Source dataset: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07622471B2

Reaction notes

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