反应详情

The above-obtained 2-chloro-5-methoxypyridine (4.0 g) in hydrazine monohydrate (30 mL) was stirred at 100° C. for 24 hours, and then cooled in air. The reaction solvent was removed under reduced pressure, and the residue was partitioned by use of chloroform and aqueous 1N sodium hydroxide. The organic layer was dried over magnesium sulfate anhydrate, followed by filtration. The solvent was removed under reduced pressure, to thereby give 2-hydrazino-5-methoxypyridine as an oily product (705 mg, 18%).

1. temperaturecooled in air
2. customThe reaction solvent was removed under reduced pressure
3. customthe residue was partitioned by use of chloroform and aqueous 1N sodium hydroxide
4. dry with materialThe organic layer was dried over magnesium sulfate anhydrate
5. filtrationfollowed by filtration
6. customThe solvent was removed under reduced pressure