Sodium Methoxide → HCID 23090365, compound

HRID 1437270Notes

Reaction equation

HRID 1437270 reaction equation
[CH3:1][O-:2].[Na+].C([O:6][C:7]([C:9]1[CH:13]=[C:12]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][N:15]=2)[N:11]([C:21]2[N:22]=[N:23][C:24](Cl)=[CH:25][CH:26]=2)[N:10]=1)=[O:8])C>CO>[Cl:20][C:17]1[CH:18]=[CH:19][C:14]([C:12]2[N:11]([C:21]3[N:22]=[N:23][C:24]([O:2][CH3:1])=[CH:25][CH:26]=3)[N:10]=[C:9]([C:7]([OH:6])=[O:8])[CH:13]=2)=[N:15][CH:16]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 86605436HCID 86605436, compound

Product 1

HCID 23090365HCID 23090365, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Sodium methoxide (150 mg) was added to the above-obtained 1-(6-chloro-3-pyridazinyl)-5-(5-chloro-2-pyridyl)pyrazole-3-carboxylic acid ethyl ester (500 mg) in methanol (10 mL), followed by stirring at room temperature for 15 hours. The reaction mixture was partitioned by use of aqueous 1N hydrochloric acid and chloroform. The organic layer was dried over sodium sulfate anhydrate, followed by filtration. The solvent was removed under reduced pressure, to thereby give the title compound as an amorphous product (483 mg, >100%).

Workup

  1. customThe reaction mixture was partitioned by use of aqueous 1N hydrochloric acid and chloroform
  2. dry with materialThe organic layer was dried over sodium sulfate anhydrate
  3. filtrationfollowed by filtration
  4. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-db41abace14e4e999eb2b32c0edddc49
Source dataset
uspto-grants-2009_11
Patent number
US07622471B2

Reaction notes

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