Sodium Methoxide → HCID 23090365, compound

Participants

Reaction Steps

Sodium methoxide (150 mg) was added to the above-obtained 1-(6-chloro-3-pyridazinyl)-5-(5-chloro-2-pyridyl)pyrazole-3-carboxylic acid ethyl ester (500 mg) in methanol (10 mL), followed by stirring at room temperature for 15 hours. The reaction mixture was partitioned by use of aqueous 1N hydrochloric acid and chloroform. The organic layer was dried over sodium sulfate anhydrate, followed by filtration. The solvent was removed under reduced pressure, to thereby give the title compound as an amorphous product (483 mg, >100%).

Provenance & Evidence