Lithium hydroxide, monohydrate → HCID 23715462, compound

HRID 1437273Notes

Reaction equation

HRID 1437273 reaction equation
O.[OH-].[Li+:3].C[O:5][C:6]([C:8]1[CH:12]=[C:11]([C:13]2[N:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[N:10]([C:19]2[CH:20]=[N:21][C:22]([O:25][CH3:26])=[CH:23][CH:24]=2)[N:9]=1)=[O:7]>CO>[Li+:3].[CH3:26][O:25][C:22]1[N:21]=[CH:20][C:19]([N:10]2[C:11]([C:13]3[N:14]=[N:15][CH:16]=[CH:17][CH:18]=3)=[CH:12][C:8]([C:6]([O-:7])=[O:5])=[N:9]2)=[CH:24][CH:23]=1

Participants

4

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 23143813HCID 23143813, compound

Product 1

HCID 23715462HCID 23715462, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Lithium hydroxide monohydrate (42 mg) was added to the above-obtained 1-(6-methoxy-3-pyridyl)-5-(3-pyridazinyl)pyrazole-3-carboxylic acid methyl ester (309 mg) in methanol (20 mL), and the resultant mixture was refluxed under heat for 18 hours, and then cooled in air. The reaction solvent was removed under reduced pressure, to thereby give the title compound as an amorphous product (322 mg, >100%).

Workup

  1. temperatureunder heat for 18 hours
  2. temperaturecooled in air
  3. customThe reaction solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-429aad47431b473e8d33dbc16dbdc0e6
Source dataset
uspto-grants-2009_11
Patent number
US07622471B2

Reaction notes

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