Methyl iodide → (R)-tert-Butyl 3-methoxypyrrolidine-1-carboxylate

HRID 1437281Notes

Reaction equation

[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][C@@H:10]([OH:13])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:14]I>>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][C@@H:10]([O:13][CH3:14])[CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 6544479tert-Butyl (3R)-3-hydroxypyrrolidine-1-carboxylate

Product 1

HCID 34179484(R)-tert-Butyl 3-methoxypyrrolidine-1-carboxylate

Procedure

The general procedure of Referential Example 106 was repeated through use of (3R)-3-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester (0.955 g) and methyl iodide (0.47 mL), to thereby give the title compound as an oily product (0.899 g, 89%).

Sources & evidence

ORD record: ord-428f4183694e49599de3c1e888af986e
Source dataset: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07622471B2

Reaction notes

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