Tert-butyl 3-oxopiperazine-1-carboxylate → 1-Methylpiperazin-2-one--hydrogen chloride (1/1)

HRID 1437282Notes

Reaction equation

HRID 1437282 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][NH:11][C:10](=[O:14])[CH2:9]1)=O)(C)(C)C.[ClH:15].O1CCOC[CH2:17]1>>[ClH:15].[CH3:17][N:11]1[CH2:12][CH2:13][NH:8][CH2:9][C:10]1=[O:14]

Participants

3

Reactant 2

HCID 3157178Tert-butyl 3-oxopiperazine-1-carboxylateHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 170607661-Methylpiperazin-2-one--hydrogen chloride (1/1)

Procedure

4N HCl-dioxane (20 mL) was added to 3-oxopiperazine-1-carboxylic acid tert-butyl ester (2.06 g) obtained from Referential Example 90, followed by stirring at room temperature for 1 hour. The reaction solvent was removed under reduced pressure, to thereby give the title compound as an oily product (1.44 g, 99%).

Workup

  1. customThe reaction solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-ed5b508a0e3d451aa4581f481b4055fe
Source dataset
uspto-grants-2009_11
Patent number
US07622471B2

Reaction notes

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