Tert-butyl 3-oxopiperazine-1-carboxylate → 1-Methylpiperazin-2-one--hydrogen chloride (1/1)

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Reaction Steps

4N HCl-dioxane (20 mL) was added to 3-oxopiperazine-1-carboxylic acid tert-butyl ester (2.06 g) obtained from Referential Example 90, followed by stirring at room temperature for 1 hour. The reaction solvent was removed under reduced pressure, to thereby give the title compound as an oily product (1.44 g, 99%).

Provenance & Evidence