反应详情

Crude butyl ester (a) (55.25 g, max 0.207 mol) was dissolved in dry tetrahydrofuran (320 ml) and cooled in an ice/salt bath. To this was added slowly, over 1 hour, potassium t-butoxide in tetrahydrofuran (1 M, 220 ml, 0.22 mol). After 0.5 hour water and petroleum ether were added and the mixture filtered quickly through kieselguhr. The phases were separated and the aqueous extracted with more petroleum ether (×2). The combined organic extracts were washed with brine, dried and evaporated to give a mobile orange oil (31.85 g, 86%), which was used immediately without further purification.

1. temperaturecooled in an ice/salt bath
2. additionTo this was added slowly, over 1 hour
3. filtrationthe mixture filtered quickly through kieselguhr
4. customThe phases were separated
5. extractionthe aqueous extracted with more petroleum ether (×2)
6. washThe combined organic extracts were washed with brine
7. customdried
8. customevaporated