Sodium Hydroxide → HCID 58743880, compound

HRID 1437315Notes

Reaction equation

HRID 1437315 reaction equation
C([O:5][C:6]([C:8]12[CH2:15][CH2:14][CH:11]([CH:12]=[CH:13]1)[N:10]([C:16]([O:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:17])[O:9]2)=[O:7])CCC.[OH-].[Na+]>O1CCOCC1>[CH2:19]([O:18][C:16]([N:10]1[CH:11]2[CH2:14][CH2:15][C:8]([C:6]([OH:7])=[O:5])([CH:13]=[CH:12]2)[O:9]1)=[O:17])[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 58743887HCID 58743887, compound

Product 1

HCID 58743880HCID 58743880, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of di-ester (c) (42.13 g, 0.122 mol) in 1,4-dioxane (250 ml) was added aqueous sodium hydroxide solution (0.5 M, 250 ml, 0.125 mol). The mixture was stirred for 1 hour then washed with diethyl ether (×3). The aqueous phase was adjusted to pH2 with 5 M hydrochloric acid, and extracted with ethyl acetate (×3). The combined organic extracts were washed with brine, dried and evaporated to give a cream solid (29.53 g, 84%).

Workup

  1. washthen washed with diethyl ether (×3)
  2. extractionextracted with ethyl acetate (×3)
  3. washThe combined organic extracts were washed with brine
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-e42baeebb5174431a08bc665a77b75af
Source dataset
uspto-grants-2009_11
Patent number
US07622481B2

Reaction notes

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