Sodium Hydroxide → HCID 58743880, compound

Participants

Reaction Steps

To a solution of di-ester (c) (42.13 g, 0.122 mol) in 1,4-dioxane (250 ml) was added aqueous sodium hydroxide solution (0.5 M, 250 ml, 0.125 mol). The mixture was stirred for 1 hour then washed with diethyl ether (×3). The aqueous phase was adjusted to pH2 with 5 M hydrochloric acid, and extracted with ethyl acetate (×3). The combined organic extracts were washed with brine, dried and evaporated to give a cream solid (29.53 g, 84%).

Provenance & Evidence