Hydrochloric Acid → 2-Oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazine-7-carboxylic acid

HRID 1437342Notes

Reaction equation

HRID 1437342 reaction equation
C[O:2][C:3]([C:5]1[CH:15]=[N:14][C:8]2[S:9][CH2:10][C:11](=[O:13])[NH:12][C:7]=2[CH:6]=1)=[O:4].[OH-].[Na+].Cl>>[O:13]=[C:11]1[CH2:10][S:9][C:8]2[N:14]=[CH:15][C:5]([C:3]([OH:4])=[O:2])=[CH:6][C:7]=2[NH:12]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 17981264Methyl 2-oxo-2,3-dihydro-1h-pyrido[2,3-b][1,4]thiazine-7-carboxylate

Product 1

HCID 218736922-Oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazine-7-carboxylic acidYield 95.2%

Procedure

The ester (b) (2.8 g) was hydrolysed with aqueous sodium hydroxide then acidified with 2M HCl and filtered to afford a solid (2.5 g) by the method of Example (1 h).

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-f01931cb263143da9a525b9b6c38a50a
Source dataset
uspto-grants-2009_11
Patent number
US07622481B2

Reaction notes

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