Trifluoroacetic anhydride → HCID 21873706, compound

HRID 1437349Notes

Reaction equation

HRID 1437349 reaction equation
[CH3:1][O:2][C:3]([CH2:5][O:6][C:7]1[C:8]([N+:15]([O-:17])=[O:16])=[CH:9][C:10]([CH3:14])=[N+:11]([O-])[CH:12]=1)=[O:4].[F:18][C:19]([F:30])([F:29])[C:20]([O:22]C(=O)C(F)(F)F)=[O:21]>>[CH3:1][O:2][C:3]([CH2:5][O:6][C:7]1[C:8]([N+:15]([O-:17])=[O:16])=[CH:9][C:10]([CH2:14][O:22][C:20](=[O:21])[C:19]([F:30])([F:29])[F:18])=[N:11][CH:12]=1)=[O:4]

Participants

3

Reactant 2

HCID 9845Trifluoroacetic anhydrideHCID 68701081HCID 68701081, compound

Product 1

HCID 21873706HCID 21873706, compound

Procedure

The pyridine N-oxide (d) (3.8 g) in trifluoroacetic anhydride (120 ml) was refluxed under argon for 24 hours, the solvent evaporated and the residue partitioned between chloroform and aqueous NaHCO3 (50 ml each). The aqueous fraction was re-extracted with chloroform (3×50 ml) and the combined organic solution dried and evaporated to give the product (1.8 g).

Workup

  1. customthe solvent evaporated
  2. customthe residue partitioned between chloroform and aqueous NaHCO3 (50 ml each)
  3. extractionThe aqueous fraction was re-extracted with chloroform (3×50 ml)
  4. customthe combined organic solution dried
  5. customevaporated

Sources & evidence

ORD record
ord-723e172949514d2093d74cab7edcb8f0
Source dataset
uspto-grants-2009_11
Patent number
US07622481B2

Reaction notes

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