反应详情

A solution of 2-bromo-5-methoxy-phenylamine (16.1 g, 80 mmol), 2,2-dimethyl-[1,3]dioxane-4,6-dione (Meldrum's acid) (13.7 g, 95 mmol) and triethyl orthoformate (14.1 g, 95 mmol) in ethanol (82 ml) was heated to reflux for 2 hours then allowed to cool to room temperature. Filtration and drying in vacuo afforded a white solid (25.7 g, 91%)

1. temperatureto reflux for 2 hours
2. filtrationFiltration
3. customdrying in vacuo