HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon Dioxide → 8-Bromo-5-methoxyquinolin-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon Dioxide | HCID 280 | — |
| Reactant | 1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) | HCID 24670 | — |
| Reactant | 5-[(2-Bromo-5-methoxy-phenylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione | HCID 68699062 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 8-Bromo-5-methoxyquinolin-4-ol | HCID 49757958 | 76% |
Reaction Steps
Dowtherm A (30 ml) was heated to reflux and enamine (a) (10 g) was added portionwise (CAUTION—vigorous evolution of CO2 and acetone) over 2 minutes. Heating was continued for a further 2 minutes then the mixture was allowed to cool to room temperature. Filtration and drying in vacuo afforded a brown solid (5.4 g, 76%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07622481B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-3df9479c37364ed497bb199194cd34dd |
| Source note | uspto-grants-2009_11 |