HCID 59427333, compound → 1,4-Dihydro-1,6-naphthyridin-4-one

HRID 1437364Notes

Reaction equation

HRID 1437364 reaction equation
CC1(C)O[C:6](=[O:8])[C:5](=[CH:9][NH:10][C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)C(=O)O1>C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1>[NH:10]1[C:11]2[C:12](=[CH:13][N:14]=[CH:15][CH:16]=2)[C:6](=[O:8])[CH:5]=[CH:9]1

Participants

3

Reactant 1

HCID 59427333HCID 59427333, compound

Product 1

HCID 40890551,4-Dihydro-1,6-naphthyridin-4-one

Reagents, catalysts & solvents 1

HCID 246701,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)Solvent

Procedure

Dowtherm A (60 mL) was brought to reflux and (a) (6.3 g, 25.4 mmol) was added portionwise over 2 minutes. The mixture was heated for a further 5 minutes then allowed to cool to room temperature. The resulting solid was washed with a small amount of cold ethanol and dried in vacuo (2.6 g, 69%).

Workup

  1. temperatureto reflux
  2. temperatureThe mixture was heated for a further 5 minutes
  3. washThe resulting solid was washed with a small amount of cold ethanol
  4. customdried in vacuo (2.6 g, 69%)

Sources & evidence

ORD record
ord-81d8a24edc5b4869bbb01293061ff3ff
Source dataset
uspto-grants-2009_11
Patent number
US07622481B2

Reaction notes

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