HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Bicarbonate → HCID 57941056, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Bicarbonate | HCID 14013 | — |
| Reactant | HOAt | HCID 181649 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 68699270 | HCID 68699270 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 57941056 | HCID 57941056 | — |
Reaction Steps
A solution of (d) (75 mg) in DMF (2 mL) was treated with ammonium bicarbonate (80 mg), 1-hydroxy-7-azabenzotriazole (57 mg), and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (60 mg). After 2.5 hours the reaction mixture was evaporated and the residue partitioned between ethyl acetate/dilute brine. The organic extract was dried and evaporated. The residue was chromatographed eluting with 2-8% methanol/dichloromethane affording a white solid (52 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07622481B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-5a517a367fdd41ba9ac5af8676ebfd3f |
| Source note | uspto-grants-2009_11 |