反应详情

A solution of (d) (75 mg) in DMF (2 mL) was treated with ammonium bicarbonate (80 mg), 1-hydroxy-7-azabenzotriazole (57 mg), and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (60 mg). After 2.5 hours the reaction mixture was evaporated and the residue partitioned between ethyl acetate/dilute brine. The organic extract was dried and evaporated. The residue was chromatographed eluting with 2-8% methanol/dichloromethane affording a white solid (52 mg).

1. customAfter 2.5 hours the reaction mixture was evaporated
2. customthe residue partitioned between ethyl acetate/dilute brine
3. extractionThe organic extract
4. customwas dried
5. customevaporated
6. customThe residue was chromatographed
7. washeluting with 2-8% methanol/dichloromethane affording a white solid (52 mg)