HCID 57941056, compound → HCID 45084570, compound

HRID 1437370Notes

Reaction equation

HRID 1437370 reaction equation
[F:1][C@@H:2]1[C@H:7]([NH:8][C@@H](C2C=CC=CC=2)C)[CH2:6][CH2:5][C@@H:4]([C:17]([NH2:19])=[O:18])[CH2:3]1>C(O)C.[OH-].[Pd+2].[OH-]>[NH2:8][C@@H:7]1[CH2:6][CH2:5][C@@H:4]([C:17]([NH2:19])=[O:18])[CH2:3][C@@H:2]1[F:1]

Participants

4

Reactant 1

HCID 57941056HCID 57941056, compound

Product 1

HCID 45084570HCID 45084570, compoundYield 135.5%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 9942167Palladium hydroxideSolvent

Procedure

A solution of of (e) (280 mg) in ethanol (15 ml) and 20% palladium(II) hydroxide on charcoal (80 mg) was hydrogenated at 50 p.s.i. for 16 hours. Filtration and evaporation afforded a white solid (230 mg).

Workup

  1. filtrationFiltration and evaporation

Sources & evidence

ORD record
ord-b107043f99464b62bf785a4b2ec0ab35
Source dataset
uspto-grants-2009_11
Patent number
US07622481B2

Reaction notes

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