Cesium carbonate → HCID 57941280, compound

HRID 1437448Notes

Reaction equation

HRID 1437448 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([N:9]2[N:13]=[C:12]3[CH:14]=[CH:15][CH:16]=[C:17]([CH3:18])[C:11]3=[N:10]2)[CH:3]=1.[CH2:19]([O:21][C:22](=[O:35])[CH2:23][C:24]1[CH:29]=[CH:28][C:27]([O:30][CH2:31][CH2:32][CH2:33]Br)=[CH:26][CH:25]=1)[CH3:20].C([O-])([O-])=O.[Cs+].[Cs+]>CC#N>[CH2:19]([O:21][C:22](=[O:35])[CH2:23][C:24]1[CH:25]=[CH:26][C:27]([O:30][CH2:31][CH2:32][CH2:33][O:8][C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][C:4]=2[N:9]2[N:13]=[C:12]3[CH:14]=[CH:15][CH:16]=[C:17]([CH3:18])[C:11]3=[N:10]2)=[CH:28][CH:29]=1)[CH3:20]

Participants

5

Reactant 3

HCID 10796Cesium carbonateHCID 9995011HCID 9995011, compoundHCID 68718127HCID 68718127, compound

Product 1

HCID 57941280HCID 57941280, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 4-chloro-2-(4-methyl-benzotriazol-2-yl)-phenol (93 mg, 0.36 mmol), [4-(3-bromo-propoxyl)-phenyl]-acetic acid ethyl ester (130 mg, 1.2 eq.) and Cs2CO3 (140 mg, 1.2 eq.) in CH3CN (10 ml) was heated to reflux for I hr. After cooling to r.t., the solid was filtered off and the filtrate was concentrated in vacuo. The crude product was purified on silica gel to give the desired compound.

Workup

  1. temperaturewas heated
  2. temperatureto reflux for I hr
  3. filtrationthe solid was filtered off
  4. concentrationthe filtrate was concentrated in vacuo
  5. customThe crude product was purified on silica gel

Sources & evidence

ORD record
ord-50abaa5c013e4c9999ea37539f558a7d
Source dataset
uspto-grants-2009_11
Patent number
US07622491B2

Reaction notes

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