Ethyl formate → HCID 13133054, compound

HRID 1437621Notes

Reaction equation

[O:1]([C:8]1[CH:9]=[C:10]([CH2:14][C:15]#[N:16])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:17](OCC)=[O:18].COC1C=CC(C(C(=O)C)C#N)=CC=1>>[O:18]=[CH:17][CH:14]([C:10]1[CH:11]=[CH:12][CH:13]=[C:8]([O:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH:9]=1)[C:15]#[N:16]

Participants

Reactant 3

HCID 8025Ethyl formate

HCID 40075m-Phenoxybenzyl cyanide

HCID 2240172-(4-methoxyphenyl)-3-oxobutanenitrile

Product 1

HCID 13133054HCID 13133054, compound

Procedure

3-Oxo-2-(3-phenoxyphenyl)propanenitrile was prepared on a 2.39 mmol scale from 3-phenoxyphenylethanenitrile and ethyl formate using the procedure described for the preparation of 2-(4-methoxyphenyl)-3-oxobutanenitrile in Example 17. The product was a viscous orange oil (84% yield).

Sources & evidence

ORD record: ord-4f4ba561970b4ed88d7c35b8f06b4e3e
Source dataset: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07622504B2

Reaction notes

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