2-Bromoacetamide → [cis-4-[[3,5-Bis(trifluoromethyl)benzyl]oxy]-3-phenylpiperidinyl]acetamide

HRID 1437636Notes

Reaction equation

HRID 1437636 reaction equation
Cl.[F:2][C:3]([F:29])([F:28])[C:4]1[CH:5]=[C:6]([CH:21]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:23]=1)[CH2:7][O:8][C@H:9]1[CH2:14][CH2:13][NH:12][CH2:11][C@H:10]1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.Br[CH2:31][C:32]([NH2:34])=[O:33]>>[F:29][C:3]([F:2])([F:28])[C:4]1[CH:5]=[C:6]([CH:21]=[C:22]([C:24]([F:27])([F:25])[F:26])[CH:23]=1)[CH2:7][O:8][C@H:9]1[CH2:14][CH2:13][N:12]([CH2:31][C:32]([NH2:34])=[O:33])[CH2:11][C@H:10]1[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 696322-BromoacetamideHCID 86606807cis-4-[[3,5-Bis(trifluoromethyl)benzyl]oxy]-3-phenylpiperidine hydrochloride

Product 1

HCID 86606814[cis-4-[[3,5-Bis(trifluoromethyl)benzyl]oxy]-3-phenylpiperidinyl]acetamideYield 52.9%

Procedure

The compound (0.15 g) obtained in Example 1 and bromoacetamide (0.094 g) were reacted and treated in the same manner as in the method described in Example 7 to obtain the title compound as colorless crystals (0.083 g, 52%).

Workup

  1. additiontreated in the same manner as in the method

Sources & evidence

ORD record
ord-fbd390582a6d42d5a954bce27c501cf0
Source dataset
uspto-grants-2009_11
Patent number
US07622487B2

Reaction notes

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