Dimethylcarbamoyl Chloride → HCID 86606816, compound

HRID 1437638Notes

Reaction equation

HRID 1437638 reaction equation
Cl.[F:2][C:3]([F:29])([F:28])[C:4]1[CH:5]=[C:6]([CH:21]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:23]=1)[CH2:7][O:8][C@H:9]1[CH2:14][CH2:13][NH:12][CH2:11][C@H:10]1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[CH3:30][N:31]([CH3:35])[C:32](Cl)=[O:33]>>[F:29][C:3]([F:2])([F:28])[C:4]1[CH:5]=[C:6]([CH:21]=[C:22]([C:24]([F:27])([F:25])[F:26])[CH:23]=1)[CH2:7][O:8][C@H:9]1[CH2:14][CH2:13][N:12]([C:32]([N:31]([CH3:35])[CH3:30])=[O:33])[CH2:11][C@H:10]1[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 6598Dimethylcarbamoyl ChlorideHCID 86606807cis-4-[[3,5-Bis(trifluoromethyl)benzyl]oxy]-3-phenylpiperidine hydrochloride

Product 1

HCID 86606816HCID 86606816, compoundYield 80.3%

Procedure

The compound (0.15 g) obtained in Example 1 and N,N-dimethylcarbamic acid chloride (0.074 g) were reacted and treated in the same manner as in the method described in Example 6 to obtain the title compound as colorless oil (0.13 g, 80%).

Workup

  1. additiontreated in the same manner as in the method

Sources & evidence

ORD record
ord-ed8dd3194c4c463ebf256ccf60170e0d
Source dataset
uspto-grants-2009_11
Patent number
US07622487B2

Reaction notes

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