Methyl Isocyanate → HCID 86606822, compound

HRID 1437672Notes

Reaction equation

HRID 1437672 reaction equation
[CH2:1]([C@H:8]1[C@@H:13]([O:14][CH2:15][C:16]2[CH:21]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:19]=[C:18]([C:26]([F:29])([F:28])[F:27])[CH:17]=2)[CH2:12][CH2:11][NH:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:30][N:31]=[C:32]=[O:33]>C1COCC1>[CH2:1]([C@H:8]1[C@@H:13]([O:14][CH2:15][C:16]2[CH:17]=[C:18]([C:26]([F:29])([F:27])[F:28])[CH:19]=[C:20]([C:22]([F:23])([F:24])[F:25])[CH:21]=2)[CH2:12][CH2:11][N:10]([C:32]([NH:31][CH3:30])=[O:33])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 86606823HCID 86606823, compound

Product 1

HCID 86606822HCID 86606822, compoundYield 61%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of the compound (0.39 g) obtained in Example 404 in THF (10 ml), methyl isocyanate (0.12 ml) was added, and the reaction mixture was stirred at room temperature for 17 hours. The solvent was evaporated under reduced pressure, and then the obtained residue was isolated and purified by silica gel column chromatography (ethyl acetate) to obtain the title compound as colorless crystals (0.27 g, 61%).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe obtained residue was isolated
  3. custompurified by silica gel column chromatography (ethyl acetate)

Sources & evidence

ORD record
ord-77ec7377c8bb4f128ab4f8d50ed44b45
Source dataset
uspto-grants-2009_11
Patent number
US07622487B2

Reaction notes

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