反应详情

The solution of 0.24 g (0.56 mmol) 5-(1-isopropyl-piperidin-4-yloxy)-pyrrolo[2,3-b]pyridine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester in 1.2 ml dioxan is treated with 0.56 ml concentrated hydrochloric acid and stirred for 16 hours under reflux. The volatile components were removed at a rotary evaporator and the residue was dried under high vacuum to give 0.19 g (98%) of the product as a brown foam which was pure enough for the next step without further purification.

1. temperatureunder reflux
2. customThe volatile components were removed at a rotary evaporator
3. customthe residue was dried under high vacuum