HRID1437722

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID24758

Sodium hydride

HNa

HCID3608067

(2-Bromoethoxy)-tert-butyldimethylsilane

C8H19BrOSi

结构：CC(C)N1CCC(Oc2cnc3[nH]c(C(=O)N4CCC(F)(F)CC4)cc3c2)CC1

HCID16727356

未命名化合物

PRODUCTS

生成物

结构：CC(C)N1CCC(Oc2cnc3c(c2)cc(C(=O)N2CCC(F)(F)CC2)n3CCO[Si](C)(C)C(C)(C)C)CC1

HCID68423931

未命名化合物

收率 29%

PROCEDURE

实验过程

The title compound was synthesized in analogy to example 18 from (4,4-difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-pyrrolo[2,3-b]pyridin-2-yl]methanone (example 13), sodium hydride and (2-bromoethoxy)-tert-butyldimethylsilane, to give the desired product as a light yellow solid (29%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6fd1fa1308a84443940ca09cc2c42a33
来源数据集: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07622466B2
来源说明: uspto-grants-2009_11

反应 SMILES

[F:1][C:2]1([F:29])[CH2:7][CH2:6][N:5]([C:8]([C:10]2[NH:28][C:13]3=[N:14][CH:15]=[C:16]([O:18][CH:19]4[CH2:24][CH2:23][N:22]([CH:25]([CH3:27])[CH3:26])[CH2:21][CH2:20]4)[CH:17]=[C:12]3[CH:11]=2)=[O:9])[CH2:4][CH2:3]1.[H-].[Na+].Br[CH2:33][CH2:34][O:35][Si:36]([C:39]([CH3:42])([CH3:41])[CH3:40])([CH3:38])[CH3:37]>>[C:39]([Si:36]([CH3:38])([CH3:37])[O:35][CH2:34][CH2:33][N:28]1[C:13]2=[N:14][CH:15]=[C:16]([O:18][CH:19]3[CH2:20][CH2:21][N:22]([CH:25]([CH3:27])[CH3:26])[CH2:23][CH2:24]3)[CH:17]=[C:12]2[CH:11]=[C:10]1[C:8]([N:5]1[CH2:6][CH2:7][C:2]([F:1])([F:29])[CH2:3][CH2:4]1)=[O:9])([CH3:42])([CH3:41])[CH3:40]