Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → {1-Cyclopropylmethyl-5-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-1H-pyrrolo[2,3-b]pyridin-2-yl}-(4,4-difluoro-piperidin-1-yl)-methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Bromomethylcyclopropane | HCID 81503 | — |
| 반응물 | (4,4-Difluoro-piperidin-1-yl)-{1-methanesulfonyl-5-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-1H-pyrrolo[2,3-b]pyridin-2-yl}-methanone | HCID 16727134 | — |
| 생성물 | {1-Cyclopropylmethyl-5-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-1H-pyrrolo[2,3-b]pyridin-2-yl}-(4,4-difluoro-piperidin-1-yl)-methanone | HCID 68424265 | 53% |
반응 단계
The title compound was synthesized in analogy to example 18 from (4,4-difluoro-piperidin-1-yl)-{1-methanesulfonyl-5-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-1H-pyrrolo[2,3-b]pyridin-2-yl}-methanone (example 20), sodium hydride and cyclopropylmethyl bromide, to give the desired product as a light yellow oil (53%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07622466B2 |
| 출처 데이터셋 | uspto-grants-2009_11 |
| ORD ID | ord-1739354c458e4cc396d5f2237be487e2 |
| 출처 메모 | uspto-grants-2009_11 |